Description
Form: Ready to use vial | Purity: ≥99% | Storage: Refrigerate
What It Is
KPV is a tripeptide (Lysine-Proline-Valine) derived from the C-terminal end of alpha-MSH. It retains the anti inflammatory properties of alpha-MSH without the melanocortin receptor activation that produces tanning and sexual effects. It is one of the most targeted anti inflammatory peptides available.
What It Does
KPV reduces systemic and local inflammation, heals the gut lining, reduces intestinal permeability (leaky gut), improves symptoms of inflammatory bowel disease, reduces skin inflammation, and has antimicrobial properties. It is particularly effective for gut-based inflammation and autoimmune conditions with a gut component.
How It Works
KPV enters cells and travels directly to the nucleus where it inhibits NF-kB, the master regulator of inflammatory gene expression. This intracellular mechanism is different from most anti inflammatory compounds, which work extracellularly. It also inhibits inflammatory cytokines including IL-1, IL-6, and TNF-alpha.
Who Benefits Most
People with IBD, Crohn’s disease, ulcerative colitis, or leaky gut. People with autoimmune conditions that have a gut component. Anyone with chronic systemic inflammation. People with skin conditions like psoriasis or eczema. Anyone looking to reduce inflammatory burden as part of a functional medicine protocol.
Protocol and Dosing
Oral or sublingual: 500 mcg to 1 mg daily for gut-specific effects. Injectable: 100 to 500 mcg subcutaneously once daily for systemic effects. Cycle length: 4 to 12 weeks.
| Route | Typical Dose | Best For |
|---|---|---|
| Oral/sublingual | 500 mcg to 1 mg | Gut inflammation |
| Subcutaneous injection | 100 to 500 mcg | Systemic inflammation |
Cautions
Excellent safety profile. Well tolerated at standard doses. No significant adverse effects reported in research. Not recommended during pregnancy.
Pairs Well With
BPC-157 for comprehensive gut healing and repair. TA-1 for immune modulation alongside anti inflammatory support. Glutathione for antioxidant support alongside inflammation reduction.
Quality and Sourcing
Sourced through United Medical Services (UMS), a compounding facility built to the same standards as a licensed 503A pharmacy. Every batch is tested for purity, sterility, potency, and identity. Certificates of Analysis are available on request.
- HPLC purity testing
- LC-MS identity confirmation
- Sterility and endotoxin testing
- Heavy metals screening
- Purity: greater than or equal to 99%
For research and investigational use by qualified healthcare practitioners only. Not for human consumption. Not for resale. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Certificate of Analysis available on request. Questions? Call or text 507-382-2881.
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